The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells

The chromatin-binding E3 ubiquitin ligase ubiquitin-like with PHD and RING finger domains 1 (UHRF1) contributes to the maintenance of aberrant DNA methylation patterning in cancer cells through multivalent histone and DNA recognition. The tandem Tudor domain (TTD) of UHRF1 is well-characterized as a...

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Vydáno v:Epigenetics Chromatin
Hlavní autoři: Vaughan, Robert M., Kupai, Ariana, Foley, Caroline A., Sagum, Cari A., Tibben, Bailey M., Eden, Hope E., Tiedemann, Rochelle L., Berryhill, Christine A., Patel, Varun, Shaw, Kevin M., Krajewski, Krzysztof, Strahl, Brian D., Bedford, Mark T., Frye, Stephen V., Dickson, Bradley M., Rothbart, Scott B.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585203/
https://ncbi.nlm.nih.gov/pubmed/33097091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-020-00366-4
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