Stromal platelet-derived growth factor receptor-β signaling promotes breast cancer metastasis in the brain

Platelet-derived growth factor receptor-beta (PDGFRβ) is a receptor tyrosine kinase found in cells of mesenchymal origin such as fibroblasts and pericytes. Activation of this receptor is dependent on paracrine ligand induction, and its preferred ligand PDGFB is released by neighboring epithelial and...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Thies, Katie A., Hammer, Anisha M., Hildreth, Blake E., Steck, Sarah A., Spehar, Jonathan M., Kladney, Raleigh D., Geisler, Jennifer A., Das, Manjusri, Russell, Luke O., Bey, Jerome F., Bolyard, Chelsea M., Pilarski, Robert, Trimboli, Anthony J., Cuitiño, Maria C., Koivisto, Christopher S., Stover, Daniel G., Schoenfield, Lynn, Otero, Jose, Godbout, Jonathan P., Chakravarti, Arnab, Ringel, Matthew D., Ramaswamy, Bhuvaneswari, Li, Zaibo, Kaur, Balveen, Leone, Gustavo, Ostrowski, Michael C., Sizemore, Steven T., Sizemore, Gina M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7581545/
https://ncbi.nlm.nih.gov/pubmed/32327406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-3731
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