A Chimeric Signal Peptide-Galectin-3 Conjugate Induces Glycosylation-Dependent Cancer Cell-Specific Apoptosis

PURPOSE: Exploitation of altered glycosylation in cancer is a major goal for the design of new cancer therapy. Here designed a novel chimeric signal peptide-Galectin-3 conjugate (sGal-3) and investigated its ability to induce cancer-specific cell death by targeting aberrantly N-glycosylated cell sur...

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Pubblicato in:Clin Cancer Res
Autori principali: Lee, Sok-Hyong, Rehman, Fatima K., Tyler, Kari, Yu, Bing, Zhang, Zhaobin, Osuka, Satoru, Zerrouqi, Abdessamad, Kaluzova, Milota, Hadjipanayis, Costas G., Cummings, Richard D., Olson, Jeffrey J., Devi, Narra S., Van Meir, Erwin G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7580863/
https://ncbi.nlm.nih.gov/pubmed/31969339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3280
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