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Synthesis, in vitro, and in vivo evaluation of novel N-phenylindazolyl diarylureas as potential anti-cancer agents

Novel N-phenylindazole based diarylureas have been designed, synthesized and evaluated as potential anticancer agents. In vitro cell viability studies of these derivatives illustrate good potency with IC(50) values in the range of 0.4–50 μM in several cancer cell lines including murine metastatic br...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Solano, Lucas N., Nelson, Grady L., Ronayne, Conor T., Jonnalagadda, Shirisha, Jonnalagadda, Sravan K., Kottke, Kaija, Chitren, Robert, Johnson, Joseph L., Pandey, Manoj K., Jonnalagadda, Subash C., Mereddy, Venkatram R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578069/
https://ncbi.nlm.nih.gov/pubmed/33087745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74572-1
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