Synthesis, in vitro, and in vivo evaluation of novel N-phenylindazolyl diarylureas as potential anti-cancer agents

Novel N-phenylindazole based diarylureas have been designed, synthesized and evaluated as potential anticancer agents. In vitro cell viability studies of these derivatives illustrate good potency with IC(50) values in the range of 0.4–50 μM in several cancer cell lines including murine metastatic br...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Solano, Lucas N., Nelson, Grady L., Ronayne, Conor T., Jonnalagadda, Shirisha, Jonnalagadda, Sravan K., Kottke, Kaija, Chitren, Robert, Johnson, Joseph L., Pandey, Manoj K., Jonnalagadda, Subash C., Mereddy, Venkatram R.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578069/
https://ncbi.nlm.nih.gov/pubmed/33087745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74572-1
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