Development of Novel Silyl Cyanocinnamic Acid Derivatives as Metabolic Plasticity Inhibitors for Cancer Treatment

Novel silyl cyanocinnamic acid derivatives have been synthesized and evaluated as potential anticancer agents. In vitro studies reveal that lead derivatives 2a and 2b have enhanced cancer cell proliferation inhibition properties when compared to the parent monocarboxylate transporter (MCT) inhibitor...

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Udgivet i:Sci Rep
Main Authors: Nelson, Grady L., Ronayne, Conor T., Solano, Lucas N., Jonnalagadda, Sravan K., Jonnalagadda, Shirisha, Rumbley, Jon, Holy, Jon, Rose-Hellekant, Teresa, Drewes, Lester R., Mereddy, Venkatram R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892925/
https://ncbi.nlm.nih.gov/pubmed/31797891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54709-7
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