Coumarin carboxylic acids as monocarboxylate transporter 1 inhibitors: In vitro and in vivo studies as potential anticancer agents

Novel N,N-dialkyl carboxy coumarins have been synthesized as potential anticancer agents via inhibition of monocarboxylate transporter 1 (MCT1). These coumarin carboxylic acids have been evaluated for their in vitro MCT1 inhibition, MTT cancer cell viability, bidirectional Caco-2 cell permeability,...

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Gepubliceerd in:Bioorg Med Chem Lett
Hoofdauteurs: Gurrapu, Shirisha, Jonnalagadda, Sravan K., Alam, Mohammad A., Ronayne, Conor T., Nelson, Grady L., Solano, Lucas N., Lueth, Erica A., Drewes, Lester R., Mereddy, Venkatram R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531278/
https://ncbi.nlm.nih.gov/pubmed/27241692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.05.054
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