Novel N,N-dialkyl cyanocinnamic acids as monocarboxylate transporter 1 and 4 inhibitors

Potent and dual monocarboxylate transporter (MCT) 1 and 4 inhibitors have been developed for the first time as potential anticancer agents based on α-cyanocinnamic acid structural template. Candidate inhibitors 1–9 have been evaluated for in vitro cell proliferation against MCT1 and MCT4 expressing...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Jonnalagadda, Shirisha, Jonnalagadda, Sravan K., Ronayne, Conor T., Nelson, Grady L., Solano, Lucas N., Rumbley, Jon, Holy, Jon, Mereddy, Venkatram R., Drewes, Lester R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6481325/
https://ncbi.nlm.nih.gov/pubmed/31040927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26760
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