Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance

Skeletal muscle insulin resistance is a prominent early feature in the pathogenesis of type 2 diabetes. In attempt to overcome this defect, we generated mice overexpressing insulin receptors (IR) specifically in skeletal muscle (IRMOE). On normal chow, IRMOE mice have body weight similar to that of...

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Veröffentlicht in:Diabetes
Hauptverfasser: Wang, Guoxiao, Yu, Yingying, Cai, Weikang, Batista, Thiago M., Suk, Sujin, Noh, Hye Lim, Hirshman, Michael, Nigro, Pasquale, Li, Mengyao Ella, Softic, Samir, Goodyear, Laurie, Kim, Jason K., Kahn, C. Ronald
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2020
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576573/
https://ncbi.nlm.nih.gov/pubmed/32868340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0439
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