Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance

Skeletal muscle insulin resistance is a prominent early feature in the pathogenesis of type 2 diabetes. In attempt to overcome this defect, we generated mice overexpressing insulin receptors (IR) specifically in skeletal muscle (IRMOE). On normal chow, IRMOE mice have body weight similar to that of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Wang, Guoxiao, Yu, Yingying, Cai, Weikang, Batista, Thiago M., Suk, Sujin, Noh, Hye Lim, Hirshman, Michael, Nigro, Pasquale, Li, Mengyao Ella, Softic, Samir, Goodyear, Laurie, Kim, Jason K., Kahn, C. Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2020
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576573/
https://ncbi.nlm.nih.gov/pubmed/32868340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0439
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados