Desensitization of the insulin receptor at an early postreceptor step by prolonged exposure to antireceptor antibody
We have used an adipocyte-like cell line, the 3T3-L1 fatty fibroblasts, to compare acute and chronic effects of autoantibodies directed against the insulin receptor. Acute exposure of the cells in tissue culture to the antibodies resulted in a blockade of insulin binding and stimulation of 2-deoxy-g...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
1979
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383058/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/284401/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.2.809 |
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