Desensitization of the insulin receptor at an early postreceptor step by prolonged exposure to antireceptor antibody

We have used an adipocyte-like cell line, the 3T3-L1 fatty fibroblasts, to compare acute and chronic effects of autoantibodies directed against the insulin receptor. Acute exposure of the cells in tissue culture to the antibodies resulted in a blockade of insulin binding and stimulation of 2-deoxy-g...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Karlsson, F. Anders, Obberghen, Emmanuel Van, Grunfeld, Carl, Kahn, C. Ronald
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1979
Schlagworte:	Biological Sciences: Cell Biology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383058/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/284401/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.2.809
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