Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation.

We have measured the turnover rate of the polypeptide subunits of the insulin receptor in cultured human lymphocytes (IM-9 line) and have investigated the mechanism of insulin-induced receptor loss. To estimate the rate of receptor degradation, lymphocytes were either pulse-labeled with [35S]methion...

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Autores principales: Kasuga, M, Kahn, C R, Hedo, J A, Van Obberghen, E, Yamada, K M
Formato: Artigo
Lenguaje:Inglês
Publicado: 1981
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC349163/
https://ncbi.nlm.nih.gov/pubmed/7031662
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