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Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation.

We have measured the turnover rate of the polypeptide subunits of the insulin receptor in cultured human lymphocytes (IM-9 line) and have investigated the mechanism of insulin-induced receptor loss. To estimate the rate of receptor degradation, lymphocytes were either pulse-labeled with [35S]methion...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Principais autores: Kasuga, M, Kahn, C R, Hedo, J A, Van Obberghen, E, Yamada, K M
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 1981
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349163/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7031662/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.11.6917
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