Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation.

We have measured the turnover rate of the polypeptide subunits of the insulin receptor in cultured human lymphocytes (IM-9 line) and have investigated the mechanism of insulin-induced receptor loss. To estimate the rate of receptor degradation, lymphocytes were either pulse-labeled with [35S]methion...

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Detalles Bibliográficos
Main Authors: Kasuga, M, Kahn, C R, Hedo, J A, Van Obberghen, E, Yamada, K M
Formato: Artigo
Idioma:Inglês
Publicado: 1981
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC349163/
https://ncbi.nlm.nih.gov/pubmed/7031662
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