Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation.
We have measured the turnover rate of the polypeptide subunits of the insulin receptor in cultured human lymphocytes (IM-9 line) and have investigated the mechanism of insulin-induced receptor loss. To estimate the rate of receptor degradation, lymphocytes were either pulse-labeled with [35S]methion...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1981
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349163/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7031662/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.11.6917 |
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