Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice

Insulin receptors (IRs) on endothelial cells may have a role in the regulation of transport of circulating insulin to its target tissues; however, how this impacts on insulin action in vivo is unclear. Using mice with endothelial-specific inactivation of the IR gene (EndoIRKO), we find that in respo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Konishi, Masahiro, Sakaguchi, Masaji, Lockhart, Samuel M., Cai, Weikang, Li, Mengyao Ella, Homan, Erica P., Rask-Madsen, Christian, Kahn, C. Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635907/
https://ncbi.nlm.nih.gov/pubmed/28923931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710625114
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