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Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice
Insulin receptors (IRs) on endothelial cells may have a role in the regulation of transport of circulating insulin to its target tissues; however, how this impacts on insulin action in vivo is unclear. Using mice with endothelial-specific inactivation of the IR gene (EndoIRKO), we find that in respo...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5635907/ https://ncbi.nlm.nih.gov/pubmed/28923931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710625114 |
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