Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

Diabetes strongly impacts protein metabolism, particularly in skeletal muscle. Insulin and IGF-1 enhance muscle protein synthesis through their receptors, but the relative roles of each in muscle proteostasis have not been fully elucidated. Using mice with muscle-specific deletion of the insulin rec...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: O’Neill, Brian T., Lee, Kevin Y., Klaus, Katherine, Softic, Samir, Krumpoch, Megan T., Fentz, Joachim, Stanford, Kristin I., Robinson, Matthew M., Cai, Weikang, Kleinridders, Andre, Pereira, Renata O., Hirshman, Michael F., Abel, E. Dale, Accili, Domenico, Goodyear, Laurie J., Nair, K. Sreekumaran, Kahn, C. Ronald
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004956/
https://ncbi.nlm.nih.gov/pubmed/27525440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86522
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