Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

Diabetes strongly impacts protein metabolism, particularly in skeletal muscle. Insulin and IGF-1 enhance muscle protein synthesis through their receptors, but the relative roles of each in muscle proteostasis have not been fully elucidated. Using mice with muscle-specific deletion of the insulin rec...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: O’Neill, Brian T., Lee, Kevin Y., Klaus, Katherine, Softic, Samir, Krumpoch, Megan T., Fentz, Joachim, Stanford, Kristin I., Robinson, Matthew M., Cai, Weikang, Kleinridders, Andre, Pereira, Renata O., Hirshman, Michael F., Abel, E. Dale, Accili, Domenico, Goodyear, Laurie J., Nair, K. Sreekumaran, Kahn, C. Ronald
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004956/
https://ncbi.nlm.nih.gov/pubmed/27525440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86522
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