Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

Diabetes strongly impacts protein metabolism, particularly in skeletal muscle. Insulin and IGF-1 enhance muscle protein synthesis through their receptors, but the relative roles of each in muscle proteostasis have not been fully elucidated. Using mice with muscle-specific deletion of the insulin rec...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: O’Neill, Brian T., Lee, Kevin Y., Klaus, Katherine, Softic, Samir, Krumpoch, Megan T., Fentz, Joachim, Stanford, Kristin I., Robinson, Matthew M., Cai, Weikang, Kleinridders, Andre, Pereira, Renata O., Hirshman, Michael F., Abel, E. Dale, Accili, Domenico, Goodyear, Laurie J., Nair, K. Sreekumaran, Kahn, C. Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004956/
https://ncbi.nlm.nih.gov/pubmed/27525440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86522
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