Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function

To determine the roles of insulin and insulin-like growth factor 1 (IGF-1) action in adipose tissue, we created mice lacking the insulin receptor (IR), IGF-1 receptor (IGF1R), or both using Cre-recombinase driven by the adiponectin promoter. Mice lacking IGF1R only (F-IGFRKO) had a ∼25% reduction in...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Boucher, Jeremie, Softic, Samir, El Ouaamari, Abdelfattah, Krumpoch, Megan T., Kleinridders, Andre, Kulkarni, Rohit N., O’Neill, Brian T., Kahn, C. Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2016
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955980/
https://ncbi.nlm.nih.gov/pubmed/27207537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0212
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