Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation

Brown adipose tissue (BAT) is rich in mitochondria and plays important roles in energy expenditure, thermogenesis and glucose homeostasis. We find that levels of mitochondrial protein succinylation and malonylation are high in BAT and subject to physiological and genetic regulation. BAT-specific del...

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Udgivet i:Mol Cell
Main Authors: Wang, Guoxiao, Meyer, Jesse G., Cai, Weikang, Softic, Samir, Li, Mengyao Ella, Verdin, Eric, Newgard, Christopher, Schilling, Birgit, Kahn, C. Ronald
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525068/
https://ncbi.nlm.nih.gov/pubmed/31000437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.03.021
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