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Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex
The human cis-prenyltransferase (hcis-PT) is an enzymatic complex essential for protein N-glycosylation. Synthesizing the precursor of the glycosyl carrier dolichol-phosphate, mutations in hcis-PT cause severe human diseases. Here, we reveal that hcis-PT exhibits a heterotetrameric assembly in solut...
Shranjeno v:
| izdano v: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7573591/ https://ncbi.nlm.nih.gov/pubmed/33077723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18970-z |
| Oznake: |
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