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Structure of KCNH2 cyclic nucleotide-binding homology domain reveals a functionally vital salt-bridge

Human KCNH2 channels (hKCNH2, ether-à-go-go [EAG]–related gene, hERG) are best known for their contribution to cardiac action potential repolarization and have key roles in various pathologies. Like other KCNH family members, hKCNH2 channels contain a unique intracellular complex, consisting of an N...

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Bibliografiske detaljer
Udgivet i:J Gen Physiol
Main Authors: Ben-Bassat, Ariel, Giladi, Moshe, Haitin, Yoni
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141593/
https://ncbi.nlm.nih.gov/pubmed/32191791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201912505
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