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The intrinsically liganded cyclic nucleotide–binding homology domain promotes KCNH channel activation

Channels in the ether-à-go-go or KCNH family of potassium channels are characterized by a conserved, C-terminal domain with homology to cyclic nucleotide–binding homology domains (CNBhDs). Instead of cyclic nucleotides, two amino acid residues, Y699 and L701, occupy the binding pocket, forming an “i...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Zhao, Yaxian, Goldschen-Ohm, Marcel P., Morais-Cabral, João H., Chanda, Baron, Robertson, Gail A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299623/
https://ncbi.nlm.nih.gov/pubmed/28122815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611701
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