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The intrinsically liganded cyclic nucleotide–binding homology domain promotes KCNH channel activation
Channels in the ether-à-go-go or KCNH family of potassium channels are characterized by a conserved, C-terminal domain with homology to cyclic nucleotide–binding homology domains (CNBhDs). Instead of cyclic nucleotides, two amino acid residues, Y699 and L701, occupy the binding pocket, forming an “i...
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| Publicado no: | J Gen Physiol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5299623/ https://ncbi.nlm.nih.gov/pubmed/28122815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611701 |
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