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Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels
KCNH voltage-gated potassium channels (EAG, ERG, and ELK) play significant roles in neuronal and cardiac excitability. They contain cyclic nucleotide-binding homology domains (CNBHDs) but are not directly regulated by cyclic nucleotides. Instead, the CNBHD ligand-binding cavity is occupied by an int...
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| Publicado no: | J Gen Physiol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5881448/ https://ncbi.nlm.nih.gov/pubmed/29567795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711989 |
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