Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex

The human cis-prenyltransferase (hcis-PT) is an enzymatic complex essential for protein N-glycosylation. Synthesizing the precursor of the glycosyl carrier dolichol-phosphate, mutations in hcis-PT cause severe human diseases. Here, we reveal that hcis-PT exhibits a heterotetrameric assembly in solut...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Bar-El, Michal Lisnyansky, Vaňková, Pavla, Yeheskel, Adva, Simhaev, Luba, Engel, Hamutal, Man, Petr, Haitin, Yoni, Giladi, Moshe
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573591/
https://ncbi.nlm.nih.gov/pubmed/33077723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18970-z
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