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Coupling of HSP72 α-Helix Subdomains by the Unexpected Irreversible Targeting of Lysine-56 over Cysteine-17; Coevolution of Covalent Bonding

Covalent inhibition has recently gained a resurgence of interest in several drug discovery areas. The expansion of this approach is based on evidence elucidating the selectivity and potency of covalent inhibitors when bound to particular amino acids of a biological target. The unexpected covalent in...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Aljoundi, Aimen, El Rashedy, Ahmed, Appiah-Kubi, Patrick, Soliman, Mahmoud E. S.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7570744/
https://ncbi.nlm.nih.gov/pubmed/32947765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25184239
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