Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

Protein glycosylation events that happen early in the secretory pathway are often dysregulated during tumorigenesis. These events can be probed, in principle, by monosaccharides with bioorthogonal tags that would ideally be specific for distinct glycan subtypes. However, metabolic interconversion in...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Debets, Marjoke F., Tastan, Omur Y., Wisnovsky, Simon P., Malaker, Stacy A., Angelis, Nikolaos, Moeckl, Leonhard K. R., Choi, Junwon, Flynn, Helen, Wagner, Lauren J. S., Bineva-Todd, Ganka, Antonopoulos, Aristotelis, Cioce, Anna, Browne, William M., Li, Zhen, Briggs, David C., Douglas, Holly L., Hess, Gaelen T., Agbay, Anthony J., Roustan, Chloe, Kjaer, Svend, Haslam, Stuart M., Snijders, Ambrosius P., Bassik, Michael C., Moerner, W. E., Li, Vivian S. W., Bertozzi, Carolyn R., Schumann, Benjamin
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2020
Предметы:
Physical Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568240/
https://ncbi.nlm.nih.gov/pubmed/32989128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007297117
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