Notum deacylates octanoylated ghrelin

OBJECTIVES: The only proteins known to be modified by O-linked lipidation are Wnts and ghrelin, and enzymatic removal of this post-translational modification inhibits ligand activity. Indeed, the Wnt-deacylase activity of Notum is the basis of its ability to act as a feedback inhibitor of Wnt signal...

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Bibliographic Details
Published in:Mol Metab
Main Authors: Zhao, Yuguang, Schuhmacher, Laura-Nadine, Roberts, Morgan, Kakugawa, Satoshi, Bineva-Todd, Ganka, Howell, Steve, O'Reilly, Nicola, Perret, Christine, Snijders, Ambrosius P., Vincent, Jean-Paul, Jones, E. Yvonne
Format: Artigo
Language:Inglês
Published: Elsevier 2021
Subjects:
Brief Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010218/
https://ncbi.nlm.nih.gov/pubmed/33647468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2021.101201
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