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Notum is required for neural and head induction via Wnt deacylation, oxidation and inactivation
Secreted Wnt morphogens are essential for embryogenesis and homeostasis, and require a lipid/palmitoleoylate modification for receptor binding and activity. Notum is a secreted Wnt antagonist that belongs to the α/β hydrolase superfamily, but its mechanism of action and roles in vertebrate embryogen...
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| Publié dans: | Dev Cell |
|---|---|
| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375027/ https://ncbi.nlm.nih.gov/pubmed/25771893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.02.014 |
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