Notum is required for neural and head induction via Wnt deacylation, oxidation and inactivation

Secreted Wnt morphogens are essential for embryogenesis and homeostasis, and require a lipid/palmitoleoylate modification for receptor binding and activity. Notum is a secreted Wnt antagonist that belongs to the α/β hydrolase superfamily, but its mechanism of action and roles in vertebrate embryogen...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Dev Cell
Prif Awduron: Zhang, Xinjun, Cheong, Seong-Moon, Amado, Nathalia G., Reis, Alice H., MacDonald, Bryan T., Zebisch, Matthias, Jones, E. Yvonne, Abreu, Jose Garcia, He, Xi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375027/
https://ncbi.nlm.nih.gov/pubmed/25771893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.02.014
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