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Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum
The hormone melatonin, secreted from the pineal gland, mediates multiple physiological effects including modulation of Wnt/β‐catenin signalling. The Wnt palmitoleate lipid modification is essential for its signalling activity, while the carboxylesterase Notum can remove the lipid from Wnt and inacti...
Uloženo v:
| Vydáno v: | J Pineal Res |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
John Wiley and Sons Inc.
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7027535/ https://ncbi.nlm.nih.gov/pubmed/31876313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jpi.12630 |
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