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Caffeine inhibits Notum activity by binding at the catalytic pocket
Notum inhibits Wnt signalling via enzymatic delipidation of Wnt ligands. Restoration of Wnt signalling by small molecule inhibition of Notum may be of therapeutic benefit in a number of pathologies including Alzheimer’s disease. Here we report Notum activity can be inhibited by caffeine (IC(50) 19 µ...
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| Publicado no: | Commun Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7544826/ https://ncbi.nlm.nih.gov/pubmed/33033363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01286-5 |
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