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Caffeine inhibits Notum activity by binding at the catalytic pocket
Notum inhibits Wnt signalling via enzymatic delipidation of Wnt ligands. Restoration of Wnt signalling by small molecule inhibition of Notum may be of therapeutic benefit in a number of pathologies including Alzheimer’s disease. Here we report Notum activity can be inhibited by caffeine (IC(50) 19 µ...
Guardat en:
| Publicat a: | Commun Biol |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7544826/ https://ncbi.nlm.nih.gov/pubmed/33033363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01286-5 |
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