Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8

[Image: see text] Misregulation of Wnt signaling is common in human cancer. The development of small molecule inhibitors against the Wnt receptor, frizzled (FZD), may have potential in cancer therapy. During small molecule screens, we observed binding of carbamazepine to the cysteine-rich domain (CR...

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Bibliographic Details
Published in:J Med Chem
Main Authors: Zhao, Yuguang, Ren, Jingshan, Hillier, James, Lu, Weixian, Jones, E. Yvonne
Format: Artigo
Language:Inglês
Published: American Chemical Society 2020
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104226/
https://ncbi.nlm.nih.gov/pubmed/32049522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b02020
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