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Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1
Wnt morphogens control embryonic development and homeostasis in adult tissues. In vertebrates the N-terminal WIF domain (WIF-1(WD)) of Wnt inhibitory factor 1 (WIF-1) binds Wnt ligands. Our crystal structure of WIF-1(WD) reveals a previously unidentified binding site for phospholipid; two acyl chain...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3430870/ https://ncbi.nlm.nih.gov/pubmed/21743455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2081 |
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