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Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
LDL-receptor-related protein 6 (LRP6), alongside Frizzled receptors, transduces Wnt signaling across the plasma membrane. The LRP6 ectodomain comprises four tandem β-propeller–EGF-like domain (PE) pairs which harbor binding sites for Wnt morphogens and their antagonists including Dickkopf 1 (Dkk1)....
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3564486/ https://ncbi.nlm.nih.gov/pubmed/22000855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.09.007 |
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