Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains

Low-density lipoprotein receptor-related protein 6 (LRP6) is a coreceptor of the β-catenin-dependent Wnt signaling pathway. The LRP6 ectodomain binds Wnt proteins, as well as Wnt inhibitors such as sclerostin (SOST), which negatively regulates Wnt signaling in osteocytes. Although LRP6 ectodomain 1...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Kim, Jinuk, Han, Wonhee, Park, Taeyong, Kim, Eun Jin, Bang, Injin, Lee, Hyun Sik, Jeong, Yejin, Roh, Kyeonghwan, Kim, Jeesoo, Kim, Jong-Seo, Kang, Chanhee, Seok, Chaok, Han, Jin-Kwan, Choi, Hee-Jung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585440/
https://ncbi.nlm.nih.gov/pubmed/33097721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19155-4
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