The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6

The glycoprotein sclerostin has been identified as a negative regulator of bone growth. It exerts its function by interacting with the Wnt co-receptor LRP5/6, blocks the binding of Wnt factors and thereby inhibits Wnt signalling. Neutralizing anti-sclerostin antibodies are able to restore Wnt activi...

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Main Authors: V. Boschert, C. Frisch, J. W. Back, K. van Pee, S. E. Weidauer, E.-M. Muth, P. Schmieder, M. Beerbaum, A. Knappik, P. Timmerman, T. D. Mueller
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2016-01-01
Colecção:Open Biology
Assuntos:
sclerostin
neutralizing antibody
osteoporosis
phage display
wnt signalling
Acesso em linha:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160120
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