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Crystallization and preliminary X-ray crystallographic analysis of the sclerostin-neutralizing Fab AbD09097
The secreted cystine-knot protein sclerostin was first identified from genetic screening of patients suffering from the rare bone-overgrowth diseases sclerosteosis and van Buchem disease. Sclerostin acts a negative regulator of bone growth through inhibiting the canonical Wnt signalling cascade by b...
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| Vydáno v: | Acta Crystallogr F Struct Biol Commun |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
International Union of Crystallography
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4388170/ https://ncbi.nlm.nih.gov/pubmed/25849496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X1500360X |
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