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Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains
Low-density lipoprotein receptor-related protein 6 (LRP6) is a coreceptor of the β-catenin-dependent Wnt signaling pathway. The LRP6 ectodomain binds Wnt proteins, as well as Wnt inhibitors such as sclerostin (SOST), which negatively regulates Wnt signaling in osteocytes. Although LRP6 ectodomain 1...
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| 發表在: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7585440/ https://ncbi.nlm.nih.gov/pubmed/33097721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19155-4 |
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