Structural Insights into the Inhibition of Wnt Signaling by Cancer Antigen 5T4/Wnt-Activated Inhibitory Factor 1

The tumor antigen 5T4/WAIF1 (Wnt-activated inhibitory factor 1; also known as Trophoblast glycoprotein TPBG) is a cell surface protein targeted in multiple cancer immunotherapy clinical trials. Recently, it has been shown that 5T4/WAIF1 inhibits Wnt/β-catenin signaling, a signaling system central to...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhao, Yuguang, Malinauskas, Tomas, Harlos, Karl, Jones, E. Yvonne
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cell Press 2014
Ämnen:
Short Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988984/
https://ncbi.nlm.nih.gov/pubmed/24582434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.01.009
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