Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7

Glyco-immune checkpoint receptors, molecules that inhibit immune cell activity following binding to glycosylated cell-surface antigens, are emerging as attractive targets for cancer immunotherapy. Defining biologically relevant ligands that bind and activate such receptors, however, has historically...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Wisnovsky, Simon, Möckl, Leonhard, Malaker, Stacy A., Pedram, Kayvon, Hess, Gaelen T., Riley, Nicholas M., Gray, Melissa A., Smith, Benjamin A. H., Bassik, Michael C., Moerner, W. E., Bertozzi, Carolyn R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865165/
https://ncbi.nlm.nih.gov/pubmed/33495350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015024118
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