Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

Protein glycosylation events that happen early in the secretory pathway are often dysregulated during tumorigenesis. These events can be probed, in principle, by monosaccharides with bioorthogonal tags that would ideally be specific for distinct glycan subtypes. However, metabolic interconversion in...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Debets, Marjoke F., Tastan, Omur Y., Wisnovsky, Simon P., Malaker, Stacy A., Angelis, Nikolaos, Moeckl, Leonhard K. R., Choi, Junwon, Flynn, Helen, Wagner, Lauren J. S., Bineva-Todd, Ganka, Antonopoulos, Aristotelis, Cioce, Anna, Browne, William M., Li, Zhen, Briggs, David C., Douglas, Holly L., Hess, Gaelen T., Agbay, Anthony J., Roustan, Chloe, Kjaer, Svend, Haslam, Stuart M., Snijders, Ambrosius P., Bassik, Michael C., Moerner, W. E., Li, Vivian S. W., Bertozzi, Carolyn R., Schumann, Benjamin
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2020
Materias:
Physical Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568240/
https://ncbi.nlm.nih.gov/pubmed/32989128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007297117
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