Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs

O-Linked α-N-acetylgalactosamine (O-Gal-NAc) glycans constitute a major part of the human glycome. They are difficult to study because of the complex interplay of 20 distinct glycosyltransferase isoenzymes that initiate this form of glycosylation, the polypeptide N-acetylgalactosaminyl-transferases...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Choi, Junwon, Wagner, Lauren J. S., Timmermans, Suzanne B. P. E., Malaker, Stacy A., Schumann, Benjamin, Gray, Melissa A., Debets, Marjoke F., Takashima, Megumi, Gehring, Jase, Bertozzi, Carolyn R.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6813768/
https://ncbi.nlm.nih.gov/pubmed/31373799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b04695
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