A computational and experimental study of O-glycosylation. Catalysis by human UDP-GalNAc polypeptide:GalNAc transferase-T2()

It is estimated that >50% of proteins are glycosylated with sugar tags that can modulate protein activity through what has been called the sugar code. Here we present the first QM/MM calculations of human GalNAc-T2, a retaining glycosyltransferase, which initiates the biosynthesis of mucin-type O...

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Udgivet i:Org Biomol Chem
Main Authors: Gómez, Hansel, Rojas, Raúl, Patel, Divya, Tabak, Lawrence A., Lluch, José M., Masgrau, Laura
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744471/
https://ncbi.nlm.nih.gov/pubmed/24643241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob42569j
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