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The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
The polypeptide GalNAc-transferases (GalNAc-Ts), that initiate mucin-type O-glycosylation, consist of a catalytic and a lectin domain connected by a flexible linker. In addition to recognizing polypeptide sequence, the GalNAc-Ts exhibit unique long-range N- and/or C-terminal prior glycosylation (Gal...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5716993/ https://ncbi.nlm.nih.gov/pubmed/29208955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02006-0 |
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