The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences

The polypeptide GalNAc-transferases (GalNAc-Ts), that initiate mucin-type O-glycosylation, consist of a catalytic and a lectin domain connected by a flexible linker. In addition to recognizing polypeptide sequence, the GalNAc-Ts exhibit unique long-range N- and/or C-terminal prior glycosylation (Gal...

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Udgivet i:Nat Commun
Main Authors: de las Rivas, Matilde, Lira-Navarrete, Erandi, Daniel, Earnest James Paul, Compañón, Ismael, Coelho, Helena, Diniz, Ana, Jiménez-Barbero, Jesús, Peregrina, Jesús M., Clausen, Henrik, Corzana, Francisco, Marcelo, Filipa, Jiménez-Osés, Gonzalo, Gerken, Thomas A., Hurtado-Guerrero, Ramon
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716993/
https://ncbi.nlm.nih.gov/pubmed/29208955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02006-0
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