Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3

Polypeptide GalNAc-transferase T3 (GalNAc-T3) regulates fibroblast growth factor 23 (FGF23) by O-glycosylating Thr178 in a furin proprotein processing motif RHT(178)R↓S. FGF23 regulates phosphate homeostasis and deficiency in GALNT3 or FGF23 results in hyperphosphatemia and familial tumoral calcinos...

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Publicat a:Nat Chem Biol
Autors principals: de las Rivas, Matilde, Paul Daniel, Earnest James, Narimatsu, Yoshiki, Compañón, Ismael, Kato, Kentaro, Hermosilla, Pablo, Thureau, Aurélien, Ceballos-Laita, Laura, Coelho, Helena, Bernadó, Pau, Marcelo, Filipa, Hansen, Lars, Maeda, Ryota, Lostao, Anabel, Corzana, Francisco, Clausen, Henrik, Gerken, Thomas A., Hurtado-Guerrero, Ramon
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923394/
https://ncbi.nlm.nih.gov/pubmed/31932717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0444-x
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