Ser and Thr acceptor preferences of the GalNAc-Ts vary among isoenzymes to modulate mucin-type O-glycosylation

A family of polypeptide GalNAc-transferases (GalNAc-Ts) initiates mucin-type O-glycosylation, transferring GalNAc onto hydroxyl groups of Ser and Thr residues of target substrates. The 20 GalNAc-T isoenzymes in humans are classified into nine subfamilies according to sequence similarity. GalNAc-Ts s...

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Detalhes bibliográficos
Publicado no:Glycobiology
Main Authors: Daniel, Earnest James Paul, las Rivas, Matilde, Lira-Navarrete, Erandi, García-García, Ana, Hurtado-Guerrero, Ramon, Clausen, Henrik, Gerken, Thomas A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Glycan Synthesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7581654/
https://ncbi.nlm.nih.gov/pubmed/32304323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwaa036
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