Emerging Paradigms for the Initiation of Mucin-type Protein O-Glycosylation by the Polypeptide GalNAc Transferase Family of Glycosyltransferases

Mammalian mucin-type O-glycosylation is initiated by a large family of ∼20 UDP-GalNAc:polypeptide α-N-acetylgalactosaminyltransferases (ppGalNAc Ts) that transfer α-GalNAc from UDP-GalNAc to Ser and Thr residues of polypeptide acceptors. Characterizing the peptide substrate specificity of each isofo...

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Autori principali: Gerken, Thomas A., Jamison, Oliver, Perrine, Cynthia L., Collette, Jeremy C., Moinova, Helen, Ravi, Lakshmeswari, Markowitz, Sanford D., Shen, Wei, Patel, Himatkumar, Tabak, Lawrence A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Glycobiology and Extracellular Matrices
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077648/
https://ncbi.nlm.nih.gov/pubmed/21349845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.218701
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