Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells

Studying posttranslational modifications classically relies on experimental strategies that oversimplify the complex biosynthetic machineries of living cells. Protein glycosylation contributes to essential biological processes, but correlating glycan structure, underlying protein, and disease-releva...

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Vydáno v:Mol Cell
Hlavní autoři: Schumann, Benjamin, Malaker, Stacy Alyse, Wisnovsky, Simon Peter, Debets, Marjoke Froukje, Agbay, Anthony John, Fernandez, Daniel, Wagner, Lauren Jan Sarbo, Lin, Liang, Li, Zhen, Choi, Junwon, Fox, Douglas Michael, Peh, Jessie, Gray, Melissa Anne, Pedram, Kayvon, Kohler, Jennifer Jean, Mrksich, Milan, Bertozzi, Carolyn Ruth
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276986/
https://ncbi.nlm.nih.gov/pubmed/32325029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.03.030
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