ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA

Lamins are important filaments forming the inner nuclear membrane. Lamin A is processed by zinc metalloproteinase (ZMPSTE24). Failure to cleave a truncated form of prelamin A—also called progerin—causes Hutchinson–Gilford progeria syndrome a well-known premature aging disease. Minor levels of proger...

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Gepubliceerd in:Cells
Hoofdauteurs: Messner, Moritz, Ghadge, Santhosh Kumar, Maurer, Thomas, Graber, Michael, Staggl, Simon, Christine Maier, Sarah, Pölzl, Gerhard, Zaruba, Marc-Michael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7563344/
https://ncbi.nlm.nih.gov/pubmed/32872320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9091981
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