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Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis?

In this review, we summarize the evidence against direct stimulation of insulin-like growth factor 1 receptors (IGF1Rs) by autoantibodies in Graves’ orbitopathy (GO) pathogenesis. We describe a model of thyroid-stimulating hormone (TSH) receptor (TSHR)/IGF1R crosstalk and present evidence that obser...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Krieger, Christine C., Neumann, Susanne, Gershengorn, Marvin C.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555308/
https://ncbi.nlm.nih.gov/pubmed/32911689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186561
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